Validated spectrophotometric estimation of esomeprazole using hydrotrophic solubilisation technique
نویسندگان
چکیده
A Simple, accurate and reproducible spectrophotometric method by Hydrotrophic Solubilisation was developed for the estimation of Esomeprazole. In the present investigation, hydrotropic solution of urea (10M) was employed as a solubilising agent to solubilise the poorly water soluble drug, esomeprazole in the tablet form and determined with the help of spectrophotometric determination in ultraviolet region. Esomeprazole showed maximum absorption at 301 nm and obeyed Beer’s law in concentration range of 10-50μg/ml. Statistical analysis of the result has been carried out revealing high accuracy and good precision.
منابع مشابه
Application of hydrotropic solubilization in spectrophotometric analysis of Esomeprazole and Itopride pharmaceutical combined tablet dosage forms
Two simple, accurate and precise methods for simultaneous estimation of Esomeprazole and Itopride in bulk drug and tablet dosage form have been described. Method-A employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. Method -B is Absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.Beer’s law was obeyed in the con...
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متن کاملApplication of hydrotropic solubilization in spectrophotometric analysis of Esomeprazole and Itopride pharmaceutical combined tablet dosage forms
Two simple, accurate and precise methods for simultaneous estimation of Esomeprazole and Itopride in bulk drug and tablet dosage form have been described. Method-A employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. Method -B is Absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.Beer’s law was obeyed in the con...
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